Guide one of five anthropomorphic Dominoes across a treacherous racetrack wherein you must set up dominoes to later knock down in ever-more-complex patterns. You cannot stop Mr. Domino. Please, try. Be my guest. You cannot.
- There are rumors of a sequel for Wii entitled Mr. D Goes to Town.
- Each character has their own seperate CG Ending sequence, and except for D?M!NO, they all die as a result of it.